Comments for Wise Young @ CareCure http://wiseyoung.wordpress.com This is a collection of my daily postings on http://carecure.org Thu, 30 Jul 2009 18:59:37 +0000 http://wordpress.com/ hourly 1 Comment on Analysis of 2009 NIH Human Stem Cell Research Policy by Joyce Horn http://wiseyoung.wordpress.com/2009/07/15/287/#comment-866 Joyce Horn Thu, 30 Jul 2009 18:59:37 +0000 http://wiseyoung.wordpress.com/?p=287#comment-866 I would have posted on Care Cure Forum, but I'm having connection issues and can't post at Care Cure. I saw some interesting feedback from Geron representative a question asked from someone on the apparalyzed forum. Their question was from: LyF has just posted a new topic entitled "A Big Letdown" in forum "Spinal Cord Injury Research, Cure & Treatment News" 7/29/09 My boyfriend is a T4 complete paraplegic Have there been any trials on animals that have been injured for longer? Once the preliminary human trials are completed, does Geron anticipate moving on to help those who have already been injured past 2 weeks? Geron's reply to her email: In preclinical studies in animal models of spinal cord injury, GRNOPC1 was injected into injured animals 7 days or 10 months post injury. Only those animals that received GRNOPC1 soon after injury (7 days) showed improvement in locomotor function (compared to animals that received a control transplant). We believe that this is due to the formation of scar tissue that occurs in the spinal cord following injury. This is the rationale for administering GRNOPC1 to patients within 7 and 14 days of the injury, and unfortunately there are currently no plans to extend to older injuries. J So my question is this, is Geron no longer going to pursue a clinical trial of GRNOPC1 for clients (incomplete SCI) that are injured over 7 to 14 days? I would have posted on Care Cure Forum, but I’m having connection issues and can’t post at Care Cure.

I saw some interesting feedback from Geron representative a question asked from someone on the apparalyzed forum. Their question was from: LyF has just posted a new topic entitled “A Big Letdown” in forum “Spinal Cord Injury Research, Cure & Treatment News” 7/29/09
My boyfriend is a T4 complete paraplegic
Have there been any trials on animals that have been injured for
longer? Once the preliminary human trials are completed, does Geron anticipate moving on to help those who have already been injured past 2 weeks?

Geron’s reply to her email: In preclinical studies in animal models of spinal cord injury, GRNOPC1 was injected into injured animals 7 days or 10 months post injury. Only those animals that received GRNOPC1 soon after injury (7 days) showed improvement in locomotor function (compared to animals that received a control transplant). We believe that this is due to the formation of scar tissue that occurs in the spinal cord following injury. This is the rationale for administering GRNOPC1 to patients within 7 and 14 days of the injury, and unfortunately there are currently no plans to extend to older injuries. J

So my question is this, is Geron no longer going to pursue a clinical trial of GRNOPC1 for clients (incomplete SCI) that are injured over 7 to 14 days?

]]> Comment on Analysis of 2009 NIH Human Stem Cell Research Policy by Wise Young http://wiseyoung.wordpress.com/2009/07/15/287/#comment-865 Wise Young Thu, 30 Jul 2009 11:31:24 +0000 http://wiseyoung.wordpress.com/?p=287#comment-865 Joyce, I don't think that there is a standard screen for genetic diseases that was available when many of the early embryonic stem cells were derived. But, in answer to your question, the early HESC lines were probably and have not been screened. Several studies, morever, have suggested that there are chromosomal and other abnormalities in these cell lines because they are so old (some since 1997) and have gone through so many generations (hundreds or thousands) in culture. Please note that the first of these cell lines (funded by Geron at the University of Wisconsin) will be going to clinical trial this summer. Wise. Joyce, I don’t think that there is a standard screen for genetic diseases that was available when many of the early embryonic stem cells were derived. But, in answer to your question, the early HESC lines were probably and have not been screened. Several studies, morever, have suggested that there are chromosomal and other abnormalities in these cell lines because they are so old (some since 1997) and have gone through so many generations (hundreds or thousands) in culture. Please note that the first of these cell lines (funded by Geron at the University of Wisconsin) will be going to clinical trial this summer.

Wise.

]]> Comment on Analysis of 2009 NIH Human Stem Cell Research Policy by Joyce Horn http://wiseyoung.wordpress.com/2009/07/15/287/#comment-852 Joyce Horn Thu, 16 Jul 2009 14:47:59 +0000 http://wiseyoung.wordpress.com/?p=287#comment-852 The Guidelines explicitly forbids funding studies of stem cells derived from blastocysts created for their stem cells. This would forbid NIH to fund studies of pluripotent human stem cells derived from blastocysts created because they contain genetic disease. Fortunately, NIH allowed use of blastocysts discarded from pre-implantation genetic testing. Does this mean the blastocysts from years ago haven't been screened for genetic problems? The Guidelines explicitly forbids funding studies of stem cells derived from blastocysts created for their stem cells. This would forbid NIH to fund studies of pluripotent human stem cells derived from blastocysts created because they contain genetic disease. Fortunately, NIH allowed use of blastocysts discarded from pre-implantation genetic testing.

Does this mean the blastocysts from years ago haven’t been screened for genetic problems?

]]> Comment on Analysis of 2009 NIH Human Stem Cell Research Policy by QuadMedic http://wiseyoung.wordpress.com/2009/07/15/287/#comment-851 QuadMedic Wed, 15 Jul 2009 11:52:39 +0000 http://wiseyoung.wordpress.com/?p=287#comment-851 Like farting against thunder Like farting against thunder

]]> Comment on Questions concerning stem cell therapies of spinal cord injury by Karen Smith http://wiseyoung.wordpress.com/questions-concerning-stem-cell-therapies-of-spinal-cord-injury/#comment-844 Karen Smith Thu, 02 Jul 2009 01:02:18 +0000 http://wiseyoung.wordpress.com/questions-concerning-stem-cell-therapies-of-spinal-cord-injury/#comment-844 My 23 year old son sustained a c5 sci 8/24/08. We are interested in finding out about the clinical trials using umbilical cord blood that are starting this Fall with NASCINet. Who do we contact? My 23 year old son sustained a c5 sci 8/24/08. We are interested in finding out about the clinical trials using umbilical cord blood that are starting this Fall with NASCINet. Who do we contact?

]]> Comment on Tricylic Antidepressant Therapy for Depression and Neuropathic Pain by Dan Brown http://wiseyoung.wordpress.com/2008/12/16/tricylic-antidepressant-therapy-for-depression-and-neuropathic-pain/#comment-843 Dan Brown Mon, 29 Jun 2009 19:25:06 +0000 http://wiseyoung.wordpress.com/2008/12/16/tricylic-antidepressant-therapy-for-depression-and-neuropathic-pain/#comment-843 Dear Dr. Young, I have seen posts on other forums quoting you as saying the prognosis for alcohol neuropathy is good, assuming the patient abstains for at least five years. Would you mind sending me your original quote and research upon which you base your statement that alcohol neuropathy is reversible? Thanks Dan Brown Dear Dr. Young,

I have seen posts on other forums quoting you as saying the prognosis for alcohol neuropathy is good, assuming the patient abstains for at least five years. Would you mind sending me your original quote and research upon which you base your statement that alcohol neuropathy is reversible?

Thanks

Dan Brown

]]> Comment on An open letter to former President George W. Bush by Mike Kadmiry http://wiseyoung.wordpress.com/2009/01/25/234/#comment-841 Mike Kadmiry Tue, 23 Jun 2009 22:38:03 +0000 http://wiseyoung.wordpress.com/2009/01/25/234/#comment-841 Mr Young, i am so appreciative for all the efforts you are making, and the tons of research you are conducting abroad and domestically, to make the spinal injury cure a reality come true. Few days ago i received an e-mail from a friend since my daughter is paralyzed and this e-mail was all about how advanced the state of Israel in Stem Cells research as well. Have you looked at their data recently? It might be worth looking at it. I also would like to ask you professor, if the countries of the world have a common data gathering in Stem Cells research? I would like to ad that your letter to Ex President Bush is very encouraging and balanced, and i hope a lot of good things will come out of it soon. Thank you Mike Kadmiry Mr Young, i am so appreciative for all the efforts you are making, and the tons of research you are conducting abroad and domestically, to make the spinal injury cure a reality come true.

Few days ago i received an e-mail from a friend since my daughter is paralyzed and this e-mail was all about how advanced the state of Israel in Stem Cells research as well. Have you looked at their data recently? It might be worth looking at it.

I also would like to ask you professor, if the countries of the world have a common data gathering in Stem Cells research?

I would like to ad that your letter to Ex President Bush is very encouraging and balanced, and i hope a lot of good things will come out of it soon.

Thank you

Mike Kadmiry

]]> Comment on A Brief Primer for Families Facing Spinal Cord injury by Marta http://wiseyoung.wordpress.com/a-brief-primer-for-families-facing-spinal-cord-injury/#comment-840 Marta Tue, 23 Jun 2009 01:11:00 +0000 http://wiseyoung.wordpress.com/a-brief-primer-for-families-facing-spinal-cord-injury/#comment-840 My nephew was injured two weeks ago. His t5 & T6 were broken. He was taken to Parkland Hospital in Dallas. His parents asked about the steroids and ice but were told by Parkland that was not an apporved method and refused to administer this. They were told this many times. He is now in Denver at Craig Clinic. My nephew was injured two weeks ago. His t5 & T6 were broken. He was taken to Parkland Hospital in Dallas. His parents asked about the steroids and ice but were told by Parkland that was not an apporved method and refused to administer this. They were told this many times. He is now in Denver at Craig Clinic.

]]> Comment on Devic’s Syndrome: Close to a Cure? by Judy Wong http://wiseyoung.wordpress.com/2008/12/18/devics-syndrome-close-to-a-cure/#comment-839 Judy Wong Fri, 19 Jun 2009 00:52:20 +0000 http://wiseyoung.wordpress.com/2008/12/18/devics-syndrome-close-to-a-cure/#comment-839 Hi Rose, I thought Imuran with prednisone works together. That is what I was taking for 21 years and had awesome results. I am now switching to rituxan-b to taper off the prednisone and no longer take imuran. Have you tried Imuran and prednisone together? To be able to take rituxan-b one must have been taking imuran first. Hi Rose,
I thought Imuran with prednisone works together. That is what I was taking for 21 years and had awesome results. I am now switching to rituxan-b to taper off the prednisone and no longer take imuran. Have you tried Imuran and prednisone together? To be able to take rituxan-b one must have been taking imuran first.

]]> Comment on Devic’s Syndrome: Close to a Cure? by Judy Wong http://wiseyoung.wordpress.com/2008/12/18/devics-syndrome-close-to-a-cure/#comment-838 Judy Wong Fri, 19 Jun 2009 00:33:26 +0000 http://wiseyoung.wordpress.com/2008/12/18/devics-syndrome-close-to-a-cure/#comment-838 I have been seeing a Doctor William Sheremata in Miami for the last 21 years. He has been treating me for Devic's. I am pleased with his treatment. I was on imuran and prednisone and now I am tapering. The new treatment I am doing is called rituxan-b. I go for an infusion every six months, and pleased with the results. I have been paralyzed twice(recovered 100%), one or the other leg gets weak. I now walk with a cane. I was blind for three months. I lost the right vision and the left eye recovered. I hope this helps. I have been seeing a Doctor William Sheremata in Miami for the last 21 years. He has been treating me for Devic’s. I am pleased with his treatment. I was on imuran and prednisone and now I am tapering. The new treatment I am doing is called rituxan-b. I go for an infusion every six months, and pleased with the results. I have been paralyzed twice(recovered 100%), one or the other leg gets weak. I now walk with a cane. I was blind for three months. I lost the right vision and the left eye recovered.

I hope this helps.

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